[{"data":1,"prerenderedAt":398},["ShallowReactive",2],{"content-site-settings":3,"content-\u002Fabout":45,"locations-data-[object Object]":172,"map-data-[object Object]":389},{"id":4,"extension":5,"meta":6,"stem":43,"__hash__":44},"dataFiles\u002Fdata\u002Fsite.json","json",{"en":7},{"siteDetails":8,"cookieControl":12,"siteLogo":16,"mainNav":21,"preNav":32,"stickyNav":33,"footerContent":34},{"organisationName":9,"siteName":10,"siteUrl":11},"Scancell Ltd","The ModiFY Study","https:\u002F\u002Fmodi-1-study.digitrial.com\u002F",{"cookieModalTitle":13,"cookieModalText":14,"nonNecessaryCookiesUsed":15},"Cookies used on this site","This website only uses non-necessary cookies to remember where you are in the process and to learn about how people view the information. We do NOT use cookies that directly identify anyone. For the best experience please click Accept all below.",true,{"url":17,"alt":18,"width":19,"height":20},"modify-logo@2x.png","Home",156.44,80,[22,25,29],{"title":23,"url":24},"Taking part","\u002Ftaking-part",{"title":26,"url":27,"target":28,"external":28},"About the study","\u002Fabout\u002F",false,{"title":30,"url":31,"target":28,"external":28},"Contact","\u002Fcontact\u002F",[],[],{"footerLogo":35,"footerCol1":39,"footerCol2":40,"footerCol3":41,"additionalInfo":42},{"url":36,"alt":37,"width":38,"height":38},"modify-logo-alt@2x.png","Scancell study logo",null,"Email: [modifyenquiries@scancell.co.uk](mailto:modifyenquiries@scancell.co.uk)\n\nTel: +44 (0)1865 582690","Scancell Ltd,\\\nBellhouse Building,\\\nSanders Road,\\\nOxford Science Park,\\\nOxford,\\\nOX4 4GD","[Privacy policy](\u002Fprivacy)\n[Cookie policy](\u002Fcookies)\n[Accessibility statement](\u002Faccessibility)\n[Site map](\u002Fsite-map)","This is a digitrial site made by morph.co.uk.","data\u002Fsite","wJ7sB88ZpZ4Gz5LpO4H3iQkv7sKS81LNYZ210IMhAb0",{"id":46,"title":26,"body":38,"description":38,"extension":5,"meta":47,"navigation":15,"path":168,"seo":169,"stem":170,"__hash__":171},"contentPages\u002Fpages\u002Fabout.en.json",{"pageTitle":26,"pageMetadata":48,"page_content":49},{"htmlTitle":26,"htmlDesc":26},[50,60,92,100,142],{"type":51,"title":52,"text":53,"image":54,"sectionSettings":59},"page_header","# About the study","A Phase 1\u002F2, Multicentre, Open-Label Study of Modi-1 in patients with head and neck cancer, renal cancer, and triple negative breast cancer",{"url":55,"alt":56,"width":57,"height":58},"modify-header-image-13@2x.png","",1100,720,{"sectionLabel":26},{"type":61,"settings":62,"text":65,"image":66,"iconList":70,"sectionSettings":88},"text_and_image",{"imgWidth":63,"imgPosition":64},"half-width","bottom","The study proposes a trial of a new vaccine, Modi-1, that consists of a combination of specific peptides. The Modi-1 peptides are combined with an adjuvant, which is designed to increase the activity of the vaccine.",{"width":67,"height":68,"url":69},460,300,"modify-content-image-9.png",[71,76,80,84],{"icon":72,"content":75},{"iconSize":73,"iconName":74},"lg","content-stethoscope","The aim of this study is to investigate the safety and effectiveness of the Modi-1 vaccine(s) in participants with head and neck cancer, renal cancer, and triple negative breast cancer.",{"icon":77,"content":79},{"iconSize":73,"iconName":78},"content-vial","In this trial, Modi-1 will be administered, either on its own (monotherapy) or in combination with a Checkpoint Inhibitor (which is given as standard of care).",{"icon":81,"content":83},{"iconSize":73,"iconName":82},"content-head","In addition, a randomized cohort is included in this study. This cohort is available to patients with head and neck cancer who are scheduled to have their tumour removed, intending to cure their cancer. In this cohort the local impact of Modi-1 (with or without pembrolizumab) will be assessed by looking at the removed tumour.",{"icon":85,"content":87},{"iconSize":73,"iconName":86},"content-syringe","Modi-1 will be administered intradermally (just under the top layer of skin). The MicronJet600™ micro-needle device will be used to administer the vaccine and contains three very small needles.",{"textAlign":89,"sectionLabel":90,"theme":91},"left","More information","mid",{"type":93,"text":94,"componentName":95,"componentOptions":96,"sectionSettings":98},"text_and_component","## Locations","StudyLocationsMap",{"mapTitle":97},"UK",{"sectionLabel":99},"Study locations map",{"type":101,"settings":102,"text":106,"cards":107,"sectionSettings":140},"text_and_cards",{"headerLevel":103,"headerFontSize":103,"maxCardsPerRow":103,"wholeClickable":28,"cardTheme":104,"alignCards":105,"alignCardContent":105},"3","primary","center","## Information about the ModiFY Study",[108,115,120,125,130,135],{"type":109,"icon":110,"title":113,"summary":114},"card_icon_text",{"iconName":111,"iconSize":112},"content-chart-1","xl","Sample size","**How many patients will be included?**\n\nUp to 138 patients",{"type":109,"icon":116,"title":118,"summary":119},{"iconName":117,"iconSize":112},"content-cross","Investigational Product","**What drug are we testing?**\n\nModi-1 vaccine",{"type":109,"icon":121,"title":123,"summary":124},{"iconName":122,"iconSize":112},"content-seedling","Study Sponsor","**Scancell Ltd**\n\nScancell is focused on developing novel immunotherapies for the treatment of cancer and infectious disease",{"type":109,"icon":126,"title":128,"summary":129},{"iconName":127,"iconSize":112},"content-edit","Study Design","A Phase 1\u002F2 study to assess the **safety**, **tolerability** (if there are any side effects, are they bearable?), **immunological activity** (does it trigger the bodies immune systems defences?) and **preliminary efficacy** (how well does it work?) of the Modi-1 vaccine in patients with head and neck cancer, renal cancer, and triple negative breast cancer",{"type":109,"icon":131,"title":133,"summary":134},{"iconName":132,"iconSize":112},"content-pie-chart","Primary outcomes","**What is the study Measuring?**\n\n* Does Modi-1 trigger an immune response?\n* Safety of Modi-1: The number of Modi-1 related side effects",{"type":109,"icon":136,"title":138,"summary":139},{"iconName":137,"iconSize":112},"content-person","Study Population","**What types of cancer is this study targeting?**\n\n 1. Head and Neck Cancer\n2. Renal Cancer\n3. Triple Negative Breast Cancer",{"sectionLabel":141,"textAlign":105},"Information about the Study",{"type":101,"settings":143,"text":146,"cards":147,"sectionSettings":166},{"headerLevel":103,"headerFontSize":103,"maxCardsPerRow":144,"wholeClickable":28,"cardTheme":145,"numberedCards":28,"alignCards":89,"alignCardContent":89},"4","secondary","## Study Team",[148,155,159,163],{"type":149,"image":150,"title":153,"summary":154},"card_image_text",{"url":56,"width":151,"height":152},900,576,"Christian Ottensmeier","**Chief Investigator**\n\nChristian is a medical oncologist with a sub-specialty in thoracic malignancies, skin cancer, and immunotherapy.",{"type":149,"image":156,"title":157,"summary":158},{"url":56,"width":151,"height":152},"Fayaz Master","**Head of Clinical Operations at Scancell**\n\nFayaz has over 20 years of clinical operations experience in early and late-stage global oncology clinical development.",{"type":149,"image":160,"title":161,"summary":162},{"url":56,"width":151,"height":152},"Robert Miller","**Medical Director at Scancell**\n\nRobert has over 32 years of experience in drug development. He is a Fellow of the Royal College of Surgeons and Fellow of the Faculty of Pharmaceutical Medicine and Royal Society of Medicine.",{"type":149,"title":164,"summary":165},"Joe Thornton","**Clinical Project Manager**\n\nJoe has over 6 years of clinical operations experience in early and late-stage global oncology clinical development.",{"sectionLabel":167},"Study Team","\u002Fpages\u002Fabout.en",{"title":26},"pages\u002Fabout.en","GImtHFRfKAB9TVyv4-RC0_7x3UdWcQZF8RVA48hNkp8",[173,195,214,234,252,271,290,308,328,349,369],{"id":174,"title":175,"body":38,"description":38,"extension":5,"map":97,"meta":176,"navigation":15,"path":191,"publishPage":15,"seo":192,"stem":193,"__hash__":194},"locations\u002Flocations\u002Fedinburgh-cancer-centre.en.json","Edinburgh Cancer Centre",{"locationName":175,"coords":177,"accordionContent":175,"sitePageContent":56,"cards":180},{"lat":178,"lng":179},"55.96166188957894","-3.232709920853224",[181,187],{"type":109,"icon":182,"title":184,"summary":185,"link":186},{"iconSize":112,"iconName":183},"content-map-marker","Address","Western General Hospital\nCrewe Road\nEdinburgh\nEH4 3XU",{"title":56},{"type":109,"icon":188,"title":189,"summary":190},{"iconSize":112,"iconName":137},"Principal Investigator","Dr Stefan Symeonides","\u002Flocations\u002Fedinburgh-cancer-centre.en",{"title":175},"locations\u002Fedinburgh-cancer-centre.en","vKMe-VfxLCu0VvL5pdMDRpJ8efxOI5sHhDtBk97JCEE",{"id":196,"title":197,"body":38,"description":38,"extension":5,"map":97,"meta":198,"navigation":15,"path":210,"publishPage":15,"seo":211,"stem":212,"__hash__":213},"locations\u002Flocations\u002Fimperial-college-healthcare-nhs-trust-london.en.json","Imperial College NHS Trust",{"locationName":197,"coords":199,"accordionContent":197,"sitePageContent":56,"cards":202},{"lat":200,"lng":201},"51.52188681427093","-0.17441711973523813",[203,207],{"type":109,"icon":204,"title":184,"summary":205,"link":206},{"iconSize":112,"iconName":183},"Imperial College London\nHammersmith Hospital\n72 Du Cane Rd\nLondon\nW12 0HS",{"title":56},{"type":109,"icon":208,"title":189,"summary":209},{"iconSize":112,"iconName":137},"Dr David Pinato","\u002Flocations\u002Fimperial-college-healthcare-nhs-trust-london.en",{"title":197},"locations\u002Fimperial-college-healthcare-nhs-trust-london.en","ZIVmBr20B5Xu96l43RVpkgmgIigN4Xeb6m4PkSTLZR8",{"id":215,"title":216,"body":38,"description":38,"extension":5,"map":97,"meta":217,"navigation":15,"path":230,"publishPage":15,"seo":231,"stem":232,"__hash__":233},"locations\u002Flocations\u002Flancashire-teaching-hospitals-nhs-foundation-trust-preston.en.json","Lancashire Teaching Hospitals",{"locationName":216,"coords":218,"accordionContent":221,"sitePageContent":56,"cards":222},{"lat":219,"lng":220},"53.790319943718615","-2.706154857444348","Lancashire Teaching Hospitals NHS Foundation Trust",[223,227],{"type":109,"icon":224,"title":184,"summary":225,"link":226},{"iconSize":112,"iconName":183},"Royal Preston Hospital\nSharoe Green Ln\nFulwood\nPreston\nPR2 9HT",{"title":56},{"type":109,"icon":228,"title":189,"summary":229},{"iconSize":112,"iconName":137},"Dr Dennis Hadjiyiannakis","\u002Flocations\u002Flancashire-teaching-hospitals-nhs-foundation-trust-preston.en",{"title":216},"locations\u002Flancashire-teaching-hospitals-nhs-foundation-trust-preston.en","wYh6lkdVwNS6RgRq010iqHYoI23fVuSeVY5hLDumWqI",{"id":235,"title":236,"body":38,"description":38,"extension":5,"map":97,"meta":237,"navigation":15,"path":248,"publishPage":15,"seo":249,"stem":250,"__hash__":251},"locations\u002Flocations\u002Fmount-vernon.en.json","Mount Vernon Cancer Care",{"locationName":236,"coords":238,"accordionContent":236,"sitePageContent":56,"cards":241},{"lat":239,"lng":240},"51.61552397577085","-0.44557159450681855",[242,245],{"type":109,"icon":243,"title":184,"summary":244},{"iconSize":73,"iconName":183},"Mount Vernon Hospital\nRickmansworth Rd,\nNorthwood \nHA6 2RN",{"type":109,"icon":246,"title":189,"summary":247},{"iconSize":73,"iconName":137},"Dr Saira Khalique","\u002Flocations\u002Fmount-vernon.en",{"title":236},"locations\u002Fmount-vernon.en","zPQ_FS_W5UjoR8CE-JwoHAH4nFnb5QOyfG8v5zVe8HM",{"id":253,"title":254,"body":38,"description":38,"extension":5,"map":97,"meta":255,"navigation":15,"path":267,"publishPage":15,"seo":268,"stem":269,"__hash__":270},"locations\u002Flocations\u002Fnottingham-university-hospitals-cancer-centre.en.json","Nottingham University Hospitals NHS Trust",{"locationName":254,"coords":256,"accordionContent":254,"sitePageContent":56,"cards":259},{"lat":257,"lng":258},"52.99136681939466","-1.1568220192481673",[260,264],{"type":109,"icon":261,"title":184,"summary":262,"link":263},{"iconSize":112,"iconName":183},"Nottingham University Hospitals NHS Trust\nCity Campus\nHucknall Road\nNottingham\nNG 1PB",{"title":56},{"type":109,"icon":265,"title":189,"summary":266},{"iconSize":112,"iconName":137},"Prof Poulam Patel","\u002Flocations\u002Fnottingham-university-hospitals-cancer-centre.en",{"title":254},"locations\u002Fnottingham-university-hospitals-cancer-centre.en","ohyLafKaesr0slZr3wZrcM8g1Sd_u8YrNV_u7n3WucU",{"id":272,"title":273,"body":38,"description":38,"extension":5,"map":97,"meta":274,"navigation":15,"path":286,"publishPage":15,"seo":287,"stem":288,"__hash__":289},"locations\u002Flocations\u002Froyal-surrey-hospital.en.json","Royal Surrey County Hospital",{"locationName":273,"coords":275,"accordionContent":278,"sitePageContent":56,"cards":279},{"lat":276,"lng":277},"51.24123845595901","-0.6084641590267243","Royal Surrey NHS Foundation Trust",[280,283],{"type":109,"icon":281,"title":184,"summary":282},{"iconSize":73,"iconName":183},"Royal Surrey Hospital\nEgerton Rd,\nGuildford\nGU2 7XX",{"type":109,"icon":284,"title":189,"summary":285},{"iconSize":73,"iconName":137},"Dr Agnieszka Michael","\u002Flocations\u002Froyal-surrey-hospital.en",{"title":273},"locations\u002Froyal-surrey-hospital.en","fScM-Mh8IX7VUF4l5yjtZDehwYvlEFj_qZiBC9C9w7o",{"id":291,"title":292,"body":38,"description":38,"extension":5,"map":97,"meta":293,"navigation":15,"path":304,"publishPage":15,"seo":305,"stem":306,"__hash__":307},"locations\u002Flocations\u002Froyal-sussex-county-hospital.en.json","Royal Sussex County Hospital",{"locationName":292,"coords":294,"accordionContent":292,"sitePageContent":56,"cards":297},{"lat":295,"lng":296},"50.821301975203355","-0.11665254201103883",[298,301],{"type":109,"icon":299,"title":184,"summary":300},{"iconSize":112,"iconName":183},"Royal Sussex County Hospital\\\nEastern Road\\\nBrighton\\\nEast Sussex\\\nBN2 5BE",{"type":109,"icon":302,"title":189,"summary":303},{"iconSize":112,"iconName":137},"Dr Rebecca Herbertson","\u002Flocations\u002Froyal-sussex-county-hospital.en",{"title":292},"locations\u002Froyal-sussex-county-hospital.en","CGmb4Y4t3RkrxyS8pOTGbyOdZzLQ28KdTbXrKNjtVko",{"id":309,"title":310,"body":38,"description":38,"extension":5,"map":97,"meta":311,"navigation":15,"path":324,"publishPage":15,"seo":325,"stem":326,"__hash__":327},"locations\u002Flocations\u002Fsheffield-teaching-hospital-nhs-foundation-trust.en.json","Sheffield Teaching Hospital",{"locationName":310,"coords":312,"accordionContent":315,"sitePageContent":56,"cards":316},{"lat":313,"lng":314},"53.379273378736904","-1.4922820439675428","Sheffield Teaching Hospitals NHS Foundation Trust",[317,321],{"type":109,"icon":318,"title":184,"summary":319,"link":320},{"iconSize":112,"iconName":183},"Cancer Clinical Trials Centre\nWeston Park Cancer Centre\nWhitham Road\nSheffield\nS10 2SJ",{"title":56},{"type":109,"icon":322,"title":189,"summary":323},{"iconSize":112,"iconName":137},"Prof Sarah Danson","\u002Flocations\u002Fsheffield-teaching-hospital-nhs-foundation-trust.en",{"title":310},"locations\u002Fsheffield-teaching-hospital-nhs-foundation-trust.en","7j-Q5F_LXEXOIL8nKJnRgW3yGxTVT-3uleTjGfktyDo",{"id":329,"title":330,"body":38,"description":38,"extension":5,"map":97,"meta":331,"navigation":15,"path":345,"publishPage":15,"seo":346,"stem":347,"__hash__":348},"locations\u002Flocations\u002Fthe-clatterbridge-cancer-centre-nhs-foundation-trust-liverpool.en.json","The Clatterbridge Cancer Centre",{"locationName":330,"coords":332,"accordionContent":335,"sitePageContent":56,"cards":336},{"lat":333,"lng":334},"53.33205346956276","-3.0283881304769786","Clatterbridge Cancer Centre NHS Foundation Trust",[337,341],{"type":109,"icon":338,"title":184,"summary":339,"link":340},{"iconSize":112,"iconName":183},"The Clatterbridge Cancer Centre\nNHS Foundation Trust\nClatterbridge Road\nBebington\nWirral\nCH63 4JY",{"title":56},{"type":109,"icon":342,"title":343,"summary":344},{"iconSize":112,"iconName":137},"Chief Investigator","Prof Christian Ottensmeier","\u002Flocations\u002Fthe-clatterbridge-cancer-centre-nhs-foundation-trust-liverpool.en",{"title":330},"locations\u002Fthe-clatterbridge-cancer-centre-nhs-foundation-trust-liverpool.en","YAUAUWLwae5bgexWMm3Mfi5i29JupY7RhHT-8aCObU8",{"id":350,"title":351,"body":38,"description":38,"extension":5,"map":97,"meta":352,"navigation":15,"path":365,"publishPage":15,"seo":366,"stem":367,"__hash__":368},"locations\u002Flocations\u002Ftorbay.en.json","Torbay Hospital",{"locationName":351,"coords":353,"accordionContent":356,"sitePageContent":56,"cards":357},{"lat":354,"lng":355},"50.481545252843986","-3.5530558852643224","Torbay and South Devon NHS Foundation Trust",[358,362],{"type":109,"icon":359,"title":184,"summary":360,"link":361},{"iconSize":73,"iconName":183},"Torbay Hospital\nNewton Rd,\nTorquay\nTQ2 7AA",{"title":56},{"type":109,"icon":363,"title":189,"summary":364},{"iconSize":73,"iconName":137},"Dr Anna Lydon","\u002Flocations\u002Ftorbay.en",{"title":351},"locations\u002Ftorbay.en","aIycRmVIYVYXihOLs2S49423ZQEcuT6eUELNK0Pm8Gg",{"id":370,"title":371,"body":38,"description":38,"extension":5,"map":97,"meta":372,"navigation":15,"path":385,"publishPage":15,"seo":386,"stem":387,"__hash__":388},"locations\u002Flocations\u002Funiversity-college-london-hospital-nhs-foundation-trust.en.json","University College London Hospital",{"locationName":371,"coords":373,"accordionContent":376,"sitePageContent":56,"cards":377},{"lat":374,"lng":375},"51.52580935938624","-0.13747268264514143","University College London Hospitals NHS Foundation Trust",[378,382],{"type":109,"icon":379,"title":184,"summary":380,"link":381},{"iconSize":112,"iconName":183},"University College London Hospital\n235 Euston Road\nLondon\nNW1 2BU",{"title":56},{"type":109,"icon":383,"title":189,"summary":384},{"iconSize":112,"iconName":137},"Dr Rowan Miller","\u002Flocations\u002Funiversity-college-london-hospital-nhs-foundation-trust.en",{"title":371},"locations\u002Funiversity-college-london-hospital-nhs-foundation-trust.en","mwOeFblgFL_M6D6iA3kN0M9y9M_gVg8wfSXZdFeL0Nc",{"id":390,"title":97,"body":38,"description":38,"extension":5,"meta":391,"navigation":15,"path":394,"seo":395,"stem":396,"__hash__":397},"locationMaps\u002Flocation-maps\u002Fuk.en.json",{"sortByRegions":28,"mapLabel":97,"maxZoomLevel":392,"regions":393,"showOpenForRecruitment":28},6,[],"\u002Flocation-maps\u002Fuk.en",{"title":97},"location-maps\u002Fuk.en","sPHH4GYQUMDrwRQl9uSdFRYgC-bWmSFakLNgCYQOs84",1791287877089]